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Start Ups - Organisations

home | | Start Ups | Organisations

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Akili
Akili

Akili Interactive is a prescription digital medicine company to directly improve cognitive impairments.. Their flagship product, EndeavorRx®, is the first ever prescription treatment delivered through a video game to treat children living with ADHD. Akili's medicines look and feel like high-end interactive action video games but, unlike typical video games, they are informed by decades of neuroscience and built with proprietary technology developed to target and treat cognitive impairments at their specific sources in the brain. Developed through the collaboration of world-renowned cognitive neuroscientists and acclaimed entertainment and technology designers, Akili has created a proprietary technology platform that represents an entirely new category of medicine.

​EndeavorRx
​EndeavorRx

EndeavorRx is indicated to improve attention function as measured by computer-based testing in children ages 8-12 years old with primarily inattentive or combined-type ADHD, who have a demonstrated attention issue. Patients who engage with EndeavorRx demonstrate improvements in a digitally assessed measure, Test of Variables of Attention (TOVA®), of sustained and selective attention and may not display benefits in typical behavioral symptoms, such as hyperactivity. EndeavorRx should be considered for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder. EndeavorRx must be prescribed by a healthcare professional. It is not intended as a stand-alone therapeutic, nor is it a substitute for your child’s medication.

Built on the Akili SSME™ proprietary technology, EndeavorRx presents specific sensory stimuli and simultaneous motor challenges designed to target neural systems in the brain related to attentional control. EndeavorRx has been rigorously evaluated across multiple clinical studies in children diagnosed with ADHD, including STARS-ADHD, a prospective, randomized, controlled study published in The Lancet Digital Health. Of 538 participants using EndeavorRx in clinical studies, 50 participants (9.3%) experienced treatment-related adverse events including frustration, headache, dizziness, emotional reaction, nausea, and aggression. There were no serious adverse events reported.

EndeavorRx a prescription only medical device. It is not intended to be used as a stand-alone therapeutic and is not a substitution for a child’s medication. EndeavorRx may not be appropriate for patients with photo-sensitive epilepsy, color blindness, or physical limitations that restrict use of a mobile device; parents should consult with their child’s healthcare provider. Families should contact their child’s healthcare professional and review the important indications, safety and caution information in the Instructions for Use before using the EndeavorRx treatment.

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Organisation

Address: 125 Broad Street 5th Floor Boston, MA 02110

Country: United States of America

Postal Address: 125 E Sir Francis Drake Blvd. Suite 300 Larkspur, CA 94939

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Big Health
Big Health

Big Health is a digital therapeutics start up that provides safe and effective non-drug alternatives for mental health. Designed by leading clinical experts, Bih Health is backed by industry-leading research and randomized controlled trials. By seamlessly integrating across the care pathway, from member engagement to billing via pharmacy benefit managers, Big Health simplify adoption for both payers and patients, providing an inclusive, scalable, and affordable approach without serious side effects.

 

Organisation

Email: hello@bighealth.com

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Cala Health
Cala Health

Cala Health is a medical technology company pioneering a new class of electrical medicine called neuroperipheral therapy.

 

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Click Therapeutics
Click Therapeutics

Click Therapeutics is biotechnology company that develops, validates, and commercializes software as prescription medical treatments for people with unmet medical needs. 

 

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Happify Health
Happify Health

 

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Limbix
Limbix

Limbix prescription digital therapeutics are based on core principles of CBT.

 

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Meru Health
Meru Health

 

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Mindstrong
Mindstrong

Mindstrong is a research-driven, consumer-focused mental healthcare company working to unlock a new virtual care model for delivering healthcare to people living with a serious mental illness (SMI) through innovations in measurement science, and care delivery. Our services are offered to people with an SMI through active partnerships with several nationwide health insurance payers. 

Mindstrong is building a platform used by their in-house care teams to deliver care coordination and evidence-based therapy and psychiatry in structured, goal-oriented sessions through our own technology. Download the Mindstrong smartphone app and complete your intake. Intake is where we'll go over your health history, current medications, and your other doctors. You'll be paired with one of our therapists or care partners, and we'll build out a care plan, together. Your first session will be schedule for you, and you can always reschedule to a time that works best for you.

Therapy happens over messaging, video, or the phone in our mobile app with our own therapists. They use evidence-based approaches in structured, goal-oriented sessions. Our approaches include Cognitive Behavioral Therapy (CBT), Coping and Emotion Regulation, Psychoeducation, Crisis Management, Reflective Listening, and Empathy.  You can also video chat with our psychiatrists. They can help with medication management. This means things like new prescriptions, and refills. Since some drugs are controlled, we'll also work with your existing psychiatrist or doctor to make sure you get what you need.

Once you download our app, our technology starts to get an idea for how you tap, scroll and type on your phone—but we never see what you're doing. How you passively use your smartphone—typing, swiping, scrolling—is a new way to measure things like your stress, mental health symptoms, and well-being. You'll also be welcomed to take industry recommended surveys to measure your symptom improvements over time. You can track your measurements in the mobile app, and they’re shared with your clinical team so they can provide you with more personalized care.

To identify the digital phenotyping features that could be clinically useful, Mindstrong used powerful machine learning methods to show that specific digital features correlate with cognitive function, clinical symptoms, and measures of brain activity in a range of clinical studies. Research volunteers completed extensive neuropsychological testing, clinical assessments of mood and cognition, and, in some cases, neuroimaging with fMRI. The results revealed a set of digital biomarkers from human-smartphone interactions that correlate highly with select cognitive measures, mood state, and brain connectivity. These interactions were comprised of taps, swipes and other touchscreen activities which were completely content-free and not reliant on capturing personal information.

 

Organisation

Address: 303 Bryant Street Mountain View, CA 94041

Country: United States of America

Email: info@mindstrong.com

Call (888) 995-2230

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Naluri
Naluri

 

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Neumora Therapeutics
Neumora Therapeutics

Neumora provides precision medicines for brain diseases. Through their proprietary precision data science platform, Neumora aim to cut through brain disease heterogeneity to match the right patient populations to targeted therapeutics and increase the probability of developing effective medicines. Their platform integrates multiple types of data to create Data Biopsy Signatures™ and Precision Phenotypes™ to map disease drivers to the defined patient subtypes including:

  • Disease Phenotype: measuring observable characteristics such as behavior, cognition, motion
  • Neural Circuitry: deconvolving patterns in the brain and their connection to phenotypes and biology
  • Digital and Molecular Biomarkers: quantifying the brain through molecular assays and digital measures
  • Cell Populations: understanding the connectivity and function of diverse cell populations
  • Genes and Pathways: identifying genetic derivers of brain diseases

To cut through the heterogeneity of neuropsychiatric disorders and neurodegenerative diseases, Neumora’s scalable data sciences platform is designed to identify and define patient subtypes by mapping the mechanisms that drive brain diseases through the development of Data Biopsy Signatures. A Data Biopsy Signature is a map of multiple, interconnected disease drivers developed by integrating multiple classes of data across genomics, imaging, EEG, digital and clinical domains. These quantitative signatures give us a deeper understanding of the drivers of the specific brain diseases which we can then use to define distinct patient phenotypes. They then map the underlying disease mechanisms as described by the Data Biopsy Signature to a Precision Phenotype™, which defines the clinically relevant characteristics of distinct patient subtypes. Instead of the current broad classifications of brain diseases, Precision Phenotypes are driven by a deep understanding of the underlying disease, leading to novel target discovery and enhanced clinical trial designs.

 

Pipeline

Neumora has a broad pipeline of novel medicines for neuropsychiatric disorders and neurodegenerative disorders, each of which will be paired with a proprietary Precision Phenotype™ to ensure a targeted approach to development. In addition to internally discovered programs, Neumora has partnered with Amgen to pursue additional complementary opportunities and maximize the value they can deliver to patients. 

 

Organisation

Address: 490 Arsenal Way, Suite 200 Watertown, MA 02472

Country: United States of America

Postal Address: 8000 Marina Blvd, Suite 700 Brisbane, CA 94005

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NeuroOne
NeuroOne

NeuroOne develops high-definition, minimally invasive diagnostic and treatment devices based on  unique thin film electrode technology. Their focus is on epilepsy and the fast‑growing neurostimulation device market. Our Technology. Advancing neuroscience.

 

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NeuroSigma
NeuroSigma

NeuroSigma is a California-based life sciences company established to develop bioelectronic technologies with the potential to transform medical practice and patients' lives. NeuroSigma is focused on TNS neuromodulation therapies based on intellectual property, licensed on an exclusive basis from the University of California, Los Angeles (UCLA), covering a wide-spectrum of disorders, including ADHD. NeuroSigma's leadership is made up of experts in business management and the healthcare industry. Together they provide extensive experience gained through years of creating and guiding successful companies and innovative medical research.

Pipeline
Pipeline

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Organisation

Address: 10960 Wilshire Blvd., Suite 1910 Los Angeles, CA 90024

Country: United States of America

Call 310-479-3100

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Omada
Omada

 

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Oura
Oura

Oura is a startup that creates sleep and activity trackers that measures a body's physiological signals to understand a person's lifestyle, The Oura Ring for example uses research grade sensors to monitor a person's sleep, activity, recovery, temperature, heart rate, stress and more.

 

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Pear Therapeutics
Pear Therapeutics

 

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Uplift
Uplift

 

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yBrain
yBrain

 

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