Alzheimer's Disease Sequencing Project (ADSP)

The Alzheimer's Disease Sequencing Project (ADSP) is a research project aiming to identify new genomic variants contributing to increased risk of developing Late-Onset Alzheimer's Disease (LOAD), to identify new genomic variants contributing to protection against developing Alzheimer's Disease (AD), to provide insight as to why individuals with known risk factor variants escape from developing Alzheimer's Disease, and to examine these factors in multi-ethnic populations as applicable in order to identify new pathways for disease prevention

 

Organisation

Country: United States of America

Email: niagads@pennmedicine.upenn.edu

Alzheimer’s Disease Genetics Global Symposium

The Alzheimer’s Disease Genetics Global Symposium: Pathway to Translation was a virtual conference has convened the dementia research community to discuss how discoveries in genetics impact biomarker development and target discovery and validation, and how to apply these findings in basic and translational research.

 

Organisation

Country: United States of America

Genome Centre For Alzheimer's Disease (GCAD)

The Genome Center for Alzheimer’s Disease (GCAD) is funded to identify genetic variants that cause, influence risk, or protect against this disorder, and to identify the underlying genes affected by these variants. The role of the Genome Center for Alzheimer’s Disease (GCAD) is to coordinate the integration and meta-analysis of all available Alzheimer’s disease (AD) relevant genetic data with the goal of identifying AD risk/causative/protective genetic variants and eventual therapeutic targets. To this end, GCAD will:

• Assemble and harmonize whole-genome (WGS)/whole-exome (WES) sequencing data.
• Build ADRD specific reference panels from GCAD WGS data for GWAS imputation.
• Call structural variants from sequencing data (insertions, deletions, copy number variations) following best practices.
• Support of Functional Genomics and Cognitive Systems Analysis of Alzheimer’s Disease Genetic and Phenotype data projects.
• Facilitate analysis of GCAD genetic and functional data collection.
• Identify candidate therapeutic targets by combining and reviewing analysis results by GCAD and other ADSP/non-ADSP projects.

 

Organisation

Country: United States of America

National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)

The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is a national genetics repository to facilitate access by qualified investigators to genotypic data for the study of genetics of late-onset Alzheimer's disease.

• Request access to NIAGADS data: submit a new or renewal application to access NIAGADS datasets.
• Submit data: provide NIAGADS documents for your dataset submission.
• Documents and Guidelines: view all NIAGADS documents and guidelines.
• Databases: Genomics Database and DASHR
• Pipelines: CoRAL, Draw+SneakPeek, SWAN for SV Analysis
• Web Servers: HAMR and SAVoR

 

Organisation

Country: United States of America

NIAGADS Data Sharing Service (DSS)

The NIAGADS Data Sharing Service (DSS) is a repository that facilitates the deposition and sharing of genomic data from the ADSP and other NIA funded Alzheimer’s Disease and Related Dementias genomic studies with approved users in the research community. The NIAGADS Data Sharing Service (DSS) was developed in 2018 to host and share data generated from the Alzheimer’s Disease Sequencing Project (ADSP) with the research community. See below for information about data hosted in each database.

 

Organisation

Country: United States of America

Email: niagads@pennmedicine.upenn.edu.

The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)

The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) provides genetic data to any qualified researcher. NIAGADS is the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site. Supported by a U24 cooperative agreement between NIA and the University of Pennsylvania, NIAGADS is a national genetics repository to facilitate access by qualified investigators to genotypic data for the study of genetics of late-onset Alzheimer's disease. The goal of the ADGC is to identify genetic variants associated with risk for AD. It has long been known that genetic factors play an important role in the development of Alzheimer's Disease. 

1. Explore: the Genomic Database provides a genome browser that allows comparison of AD GWAS summary statistics tracks to sequence variation and transcriptional regulation. Search for your favorite gene or variant to explore its genomic context and then switch to a full browser view to add additional tracks.
2. Analyze: Search strategies make it easy to ask sophisticated questions about your data. Find variants associated with alzheimer's disease datasets or explore all available searches. Upload a gene list and take advantage of our functional and pathway enrichment tool to gain new insight into an existing dataset. Browse our example search strategies for some ideas.
3. Share: Download your result for further analysis. Registered users can share strategy and analysis results with the community or generate a static link for a publication. Bookmark your favorite genes and variants and save and annotate strategies to create a personalized workspace.

NIAGADS ensures that genotypic data for the study of Alzheimer’s disease and related dementias (ADRD) is harmonized and shared with the research community at large. The centers and projects listed here work together on data deposition from start to finish – through sequencing, processing, storing, and sharing. These collaborations allow for capacity building and enhanced discovery in the field of ADRD genetics.

 

Organisation

Country: United States of America

Email: NIAGADS@pennmedicine.upenn.edu